She is the main female character of the story. Chise is a shy, clumsy girl with very little self-esteem and has poor grades in everything except for World History. She was constantly hospitalized in Tokyo during her elementary years, and thus, has very few friends (except for Akemi). She starts dating Shuji, with Akemi’s help, and tries to make her relationship work with him despite his apparently aloof personality. However, Chise is very inexperienced and does not know much about relationships to the point she reads shōjo manga for advice. She was turned into the ultimate weapon against her will and the series revolves around her and her fading humanity. As Chise’s weapon-side starts to take over, her heart stops beating, her body lacks warmth and her sense of taste and touch are dulled, but other senses (especially sight) are accentuated. Her condition worsens and her humanity seems to fade away entirely. In the final episodes of the anime, she appears to be nothing more than a cold, ruthless machine that delights in her growing, destructive powers and killing people without mercy. Her love for Shuji is the last of her humanity. Throughout the story, she tries to come to terms with her body while still trying to convince herself that she is still human. She believes that she is nothing more than a weapon designed to kill. Her boyfriend Shuji, however, is able to help her break free by showing her that she is able to protect the ones she loves, and that only a human can experience the feeling of love. This helps Chise destroy the body in which she was trapped, and she realizes that she is indeed human. This brings to question what is meant by the term "ultimate weapon" used throughout the story. Chise's soul had been the only thing that was able to destroy her body, which was claimed to be the most powerful thing in the world.